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“part pre-colloidization starch” rich for medicinal purposes auxiliary materials storehouse
    公布工夫:2007-07-22    浏览次数:999

The starch is the nature originates the richest natural multi-carbohydrate polymer, belongs to the renewable vegetative resources. The starch takes for medicinal purposes supplementary material the history to have more than 100 years, its dried noodles may take the tablet the disintegration medicinal preparation, but the starch may take a system grain of time the bond, provides the good compressibility for the powder mixture. But because PVP (polyethylene pyrrolidone) and HPMC (hydroxy third methylcellulose) and so on new for medicinal purposes excipient impact, the ordinary starch's is reducing gradually in drug industry application. What is encouraging, the scientific researchers act according to starch's structural feature, in recent years has made the very big progress to the new starch supplementary material's research work.

  The natural starch is composed of two kind of different glucose polymers, one kind is the amylose, another kind is the amylopectin. The amylose is the molecular chain which by one long, the linear dehydrated glucose unit is composed, its molecular weight is low, the inherent viscosity is good, its peroxide solution's thermodynamics stability is low under the usual density condition; The amylopectin is by one big, the complex strip molecular chain is composed, these branches composed the amylopectin to be similar to the tree molecular structure, enabled it to have the great molecular weight, the quite good peroxide solution stability and the very high inherent viscosity. In the natural starch, the amylose and amylopectin's comparative content is decided by the starch origin. 

  At present usually thought that the starch granule the structure is composed of the radiated arrangement small crystal, these crystal majority is composed of the amylopectin, but linear amylose part by disorderly condition penetration in pellet. So long as has the enough energy, usually 90℃~100℃ the hot water, may overcome between the starch crystal the binding force, then the ordinary starch will boil the starch. -永利国际 - Home

  The experiment proved that the starch binds the function is mainly makes the thick liquid after the colloidization process the starch-grains structure is destroyed, releases the starch-grains internal amylopectin to realize. But has not had by the colloidization starch-grains internal amylose the very strong disintegration function, is the very effective disintegration medicinal preparation. Therefore, through to the starch colloidization process and the colloidization proportion's control, may obtain binds, the disintegration performance starch class for medicinal purposes supplementary material differently.

  This kind new “the part pre-colloidization starch” is one kind of new supplementary material, compares the traditional starch supplementary material to have the very big superiority, it is causes in the corn starch using the heating and the machinery method the partial starch granule breakage to become one colloid, but another part still maintained the original condition, and strict control colloidization starch proportion, thus maintains binds with the disintegration performance relative stabilization. After the starch passes through this kind “the part pre-colloidization” processing, the breakage starch-grains display strongly bind the function, maintains the original condition the starch-grains to be possible to continue to play its disintegration role. Therefore, this new material simultaneously has the dual function which binds and breaks up, its cost is lower than PVP and HPMC, may substitute for chemical synthesis supplementary materials and so on PVP, HPMC to use in producing solid preparations and so on tablet and capsule.
 
 ■ is suitable in the hydrophobic medicine prepares

  “the part pre-colloidization starch” the most major characteristic is during the display binds the function, will not have the disintegration and dissolves has problems. This characteristic causes it to be suitable hydrophobic for difficult to dissolve the medicine in the tablet. Takes the adhesive by “the part pre-colloidization starch”, has prepared 500 milligrams with a fluid bed system grain of method to the acetyl amino-phenol pouch shape piece, its degree of hardness may amount to 11 kilograms, with traditional adhesive PVP preparation quite, but its disintegration time is only 1 minute, is lower than greatly by PVP takes the adhesive the tablet, thus quicker display curative effect. This kind of new starch may increase the pill as the adhesive the mechanical strength, reduces processes when the breakage rate, is suitable for a fluid bed system grain of process, because its 15% suspension's viscosity is only 300cp, with 5% starch's viscosity, this viscosity's fluidity is quite good, is advantageous in the fluid bed system grain of process operation.

  ■ disintegration function and ordinary starch quite -永利娱乐7136

  “part pre-colloidization starch” the disintegration function is mainly has not produced by the colloidization part, therefore its disintegration function and ordinary starch quite. It had the disintegration function principle was still the absorbing water inflation and the capillarity. Because this kind of new starch maintained in the preparation process certain equilibrium moisture, therefore it still could maintain stable in the humidity environment, its water absorbability is lower than the ordinary starch, and is lower than the super disintegration medicinal preparation greatly.

  ■ has the good fluidity and the lubricating ability

  “part pre-colloidization starch” microscopic assumes the spheroidal particle condition, its average grain diameter is 70 microns, has the good fluidity and the lubricating ability, uses this kind of starch to take the auxiliaries the tablet to be possible the right amount reduced lubricant amount used, and is very suitable for the direct powder sheeting process.
  With this kind of new starch coordination maltodextrin, the lactose all extracts with the direct powder sheeting law preparation's traditional Chinese medicine the piece, after the mix powder speed of flow is 5.49 milliliters/seconds, stops the angle 36.2°, the obtained tablet piece heavy difference is 0.76%, tablet degree of hardness has achieved 80N, but breaks up the time is 16 minutes. The above data shows “the part pre-colloidization starch” fully in the tablet preparation high performance.

  ■ potential many kinds of new dosage-forms -澳门永利集团304.com

  Because its water-solubility is extremely good and the transparency is high, “the part pre-colloidization starch” may use in produces one kind “the pulse type for the medicine” new controlling releases the piece as well as takes the oral the matrix.
  Uses the new starch supplementary material also to be possible to produce “the compound level type” the new pill (for example to spread again one medicine for in extranuclear bread pre-colloidization starch other medicines), thus enhances the tablet class solid medicine greatly the adaptation card.

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